![]() Partial Atrioventricular Canal (AV Canal).Complete Atrioventricular Canal (AV Canal).Package insert. Kiniksa Pharmaceuticals (UK), Ltd 2021. Novartis Pharmaceuticals Corporation 2016. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Data on file #8. Kiniksa Pharmaceuticals (UK), Ltd.FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes.Interleukin-1 blockade for the treatment of pericarditis. Buckley LF, Viscusi MM, Van Tassel BW, Abbate A.Intravenous immunoglobulin as clinical immune-modulating therapy. Colchicine administered in the first episode of acute idiopathic pericarditis: a randomized multicenter open-label study. Sambola A, Roca Luque I, Mercé J, et al.Recurrent pericarditis: still idiopathic? The pros and cons of a well-honoured term. Brucato A, Imazio M, Cremer PC, et al.Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Dinarello CA, Simon A, van der Meer JW.Recurrent pericarditis: new and emerging therapeutic options. Imazio M, Lazaros G, Brucato A, Gaita F.Quantitative pericardial delayed hyperenhancement informs clinical course in recurrent pericarditis. Quantitative assessment of pericardial delayed hyperenhancement helps identify patients with ongoing recurrences of pericarditis. RHAPSODY: rationale for and design of a pivotal Phase 3 trial to assess efficacy and safety of rilonacept, an interleukin-1 α and interleukin-1 β trap, in patients with recurrent pericaditis. Klein, AL, Imazio M, Brucato A, et al.2015 ESC guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC). ![]() Management of acute and recurrent pericarditis. Chiabrando JG, Bonaventura A, Vecchie A, et al.Complicated pericarditis: understanding risk factors and pathophysiology to inform imaging and treatment. Cremer PC, Kumar A, Kontzias A, et al.7 Below is a partial list of possible side effects based on reviews from experts in the field of pericarditis. There are limited studies assessing their utility in recurrent pericarditis, and all carry the potential risk of side effects that can complicate management. While none of the following therapies for pericarditis are FDA approved for the condition, physicians have achieved some success with these treatments. Possible side effects of treatment approaches Immunomodulators are potent steroid-sparing agents that broadly suppress or modulate the immune system 11,12.Colchicine administration does not seem to have any relevant influence on the recurrence rate or on the severity of clinical manifestations 10.Colchicine blocks tubulin polymerization, thereby nonspecifically disrupting several functions in immune cells (especially granulocytes) 7.For some patients, it has been shown that the recurrence rate is lower following the first episode of acute idiopathic pericarditis when no corticosteroids are administered 10.NSAIDs and corticosteroids nonspecifically reduce inflammation.Most treatments currently being used to manage recurrent pericarditis symptoms do not target the specific mechanism of autoinflammation primarily driven by IL-1□ and IL-1β. Pericardiectomy if all other options are exhausted.
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